Use left justification and default margins.
Readers with low vision who use magnification tend to use the left edge as a guide and not miss content. It also assists readers with neurodiverse medical conditions such as dyslexia.
Justified text should be avoided. It creates uneven spaces between letters and words
Be mindful of unnecessary space such as empty paragraphs. A screen reading tool will attempt to read an empty paragraph. Use in-built paragraph and line spacing features to increase space between paragraphs.